THE EVOLUTION OF INSOMNIA DRUG THERAPY: BENZODIAZEPINES – TRIAZOLAM

Marketed under the brand name Halcion, triazolam possesses the shortest half-life (four to six hours) of the major hypnotic benzodiazepines; thus the effects of the drug are usually completely gone by morning. It is especially useful in cases of transient insomnia, or for occasional use in chronic insomnia when sedative or antianxiety effects are not appropriate. With triazolam the onset of sleep occurs more quickly; REM sleep is delayed, but the total percentage of REM sleep is not affected. Sleep time is longer, but there is less deep sleep; there are also fewer awakenings. Triazolam has other uses as well; it can help to manage the disruptive behaviors in sleep-disturbed patients with Alzheimer’s. Furthermore, as I mentioned earlier, it may help overcome the symptoms of jet lag by causing rapid adjustments of the biological clock. Triazolam-is more rapidly absorbed than temazepam, but it poses the= risk of a number of side effects, including early-morning insomnia, memory impairment, psychotic symptoms, sleepwalking activity, and rebound insomnia if withdrawal from the drug is not handled properly.
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THE EVOLUTION OF INSOMNIA DRUG THERAPY: BENZODIAZEPINES – TRIAZOLAMMarketed under the brand name Halcion, triazolam possesses the shortest half-life (four to six hours) of the major hypnotic benzodiazepines; thus the effects of the drug are usually completely gone by morning. It is especially useful in cases of transient insomnia, or for occasional use in chronic insomnia when sedative or antianxiety effects are not appropriate. With triazolam the onset of sleep occurs more quickly; REM sleep is delayed, but the total percentage of REM sleep is not affected. Sleep time is longer, but there is less deep sleep; there are also fewer awakenings. Triazolam has other uses as well; it can help to manage the disruptive behaviors in sleep-disturbed patients with Alzheimer’s. Furthermore, as I mentioned earlier, it may help overcome the symptoms of jet lag by causing rapid adjustments of the biological clock. Triazolam-is more rapidly absorbed than temazepam, but it poses the= risk of a number of side effects, including early-morning insomnia, memory impairment, psychotic symptoms, sleepwalking activity, and rebound insomnia if withdrawal from the drug is not handled properly.*275\226\8*

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